The U.S. is experiencing a rapidly increasing frequency of drug shortages, which have caused numerous difficulties for clinicians, health care facilities, patients, and federal regulators. Drug shortages are caused by many factors, including difficulties in acquiring raw materials, manufacturing problems, regulatory issues, and business decisions, as well as many other disturbances within the supply chain. They adversely affect patient care by causing substitution of safe and effective therapies with alternative treatments; compromising or delaying medical procedures; or causing medication errors. Drug shortages also significantly burden health care provider and health care facility finances and personnel. A management strategy that includes clear policies and procedures for information gathering, decision making, collaboration, and timely communication should be established to effectively handle drug shortages.